Following the mandate given by the European Commission to the SCCS in October 2020, the Scientific Committee has just published its preliminary Opinion on the safety of the UV-filter HAA299 (nano). It has been adopted by written procedure on 22 July 2021 and is open for comments until 27 September 2021.
Background
HAA299 (nano) - INCI: “Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine” (CAS 919803-06-8) - is a cosmetic ingredient with the reported functions of UV-filter.
In its Opinion SCCS/1533/14, the SCCS concluded that “the use of non-nano HAA299 […] at a concentration up to 10% as an UV-filter in cosmetic products, does not pose a risk of systemic toxicity in humans.” But the Committee added that this “Opinion does not cover the safety evaluation of HAA299 which is composed of nano particles.””
In September 2020, a dossier was submitted requesting a safety assessment of HAA299 (nano) for use as a UV filter up to a maximum concentration of 10%.
For an exhaustive background information, see the article
• HAA299 (nano): New request for SCCS Opinion, CosmeticOBS, 9 November 2020
Opinion
1. In light of the data provided, does the SCCS consider HAA299 (nano) safe when used as a UVfilter in cosmetic products up to a maximum concentration of 10%?
The available data indicate that HAA299 (nano) is a practically insoluble material, with very low dermal absorption. Due to the very low systemic availability, the material is unlikely to exert systemic genotoxic or reproductive effects. The NOAEL of …
