In June 2026, the SCCS (Scientific Committee on Consumer Safety) accepted the European Commission’s mandate to assess the safety of phytonadione epoxide. The Scientific Committee on Consumer Safety has just published its preliminary opinion.
Background
Phytonadione Epoxide (INCI) (Vitamin K1 oxide) (CAS No.25486-55-9, EC No.247-022-9) is a synthetic or naturally occurring oxidised form of vitamin K1 (phytonadione), resulting from the epoxidation of the naphthoquinone ring. In cosmetic products, it is mainly used as a skin conditioning agent and is reported to contribute to reducing the appearance of dark circles and redness, as well as improving skin tone uniformity. It is therefore used among others in products such as eye contour creams, anti-ageing serums and formulations intended for sensitive or redness-prone skin.
To obtain a clearer understanding of the exposure conditions, use patterns and toxicological profile of Phytonadione Epoxide, the Commission launched a call for data between May 2025 and May 2026, which sought to gather comprehensive scientific information on the safety of Phytonadione Epoxide when used in cosmetic products.
For an exhaustive background information, see the article
• Phytonadione Epoxide: Request for Opinion to the SCCS, CosmeticOBS, 26 June 2026
The SCCS Opinion
In light of all data submitted during the call for data:
1. Does the SCCS consider Phytonadione Epoxide (Vitamin K1 oxide) safe when used as an ingredient in cosmetic products up to a maximum concentration …
