On August 25, 2025, the European Chemicals Agency (ECHA) launched a consultation on the Austria proposal for harmonized classification and labeling (CLH) of Dimethylaminopropylamine, notably as a reprotoxic substance and endocrine disruptor.
3-aminopropyldimethylamine (CAS No.109-55-7, EC No.203-680-9, INCI: Dimethylaminopropylamine) is an ingredient listed in the Cosing, with no function reported.
The substance is included in Annex III/62 of the European Cosmetics Regulation 1223/2009, which limits trialkylamines, trialkanolamines and their salts to 2.5% in leave-on products, and details theconditions of use in order to prevent nitrosation phenomena.
It is also listed in Annex VI/612-061-00-6 of European CLP Regulation 1272/2008, with the following classifications:
• Flam. Liq. 3, H226 - Flammable liquid and vapour
• Acute Tox. 4 (*), H302 - Harmful if swallowed
• Skin Corr. 1B, H314 - Causes severe skin burns and eye damage
• Skin Sens. 1, H317 - May cause an allergic skin reaction
Austria proposes to classify the substance as follows.
Identification
Index number
• 612-061-00-6
Chemical name
• 3-aminopropyldimethylamine; N,N-dimethyl-1,3-diaminopropane
EC number
• 203-680-9
CAS number
• 109-55-7
Classification
Hazard class and Category code(s)
• Flam. Liq. 3
• Repr. 1B
• Acute Tox. 3
• Acute Tox. 4
• STOT SE 3
• Skin Corr. 1B
• Skin Sens. 1A
• ED HH 2
• ED ENV 2
Hazard statement code(s)
• H226 - Flammable liquid and …
