Hydroxycitronellal

Background on Quantitative Risk Assessment (QRA)

Skin sensitisation leading to Allergic Contact Dermatitis (ACD) is a significant health concern associated with exposure to fragrance ingredients.
The Quantitative Risk Assessment (QRA) methodology, originally developed by industry, has undergone substantial refinement. Its updated version (QRA2) incorporates improved exposure assessment, including aggregate exposure across multiple product uses.
The SCCS acknowledged progress in QRA2 but also highlighted remaining uncertainties and methodological limitations, concluding that its suitability should be assessed on a case-by-case basis.
A recent SCCS evaluation of Citral as a case study applying the QRA2 methodology concluded that the derived safe use levels may be considered safe with regard to the induction of skin sensitisation, while also identifying a number of methodological aspects requiring further clarification and refinement. The SCCS further indicated that the applicability of QRA2 should continue to be assessed on a case-by-case basis.

Background on Hydroxycitronellal

Hydroxycitronellal (CAS No.107-75-5, EC No.203-518-7) with the chemical name “7-hydroxy-3,7-dimethyloctanal” is a fragrance ingredient widely used in cosmetic products due to its floral odour profile. It is also present in other consumer products such as household and air care products. Hydroxycitronellal is a well-known skin sensitiser and has been …