
On April 2, 2025, the European Chemicals Agency (ECHA) launched a consultation on Germany’s proposal for harmonized classification and labeling (CLH) of Acetyl Hexamethyl Tetralin, a fragrance ingredient. This consultation is open until May 30, 2025.
1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (CAS No.1506-02-1 / 21145-77-7, EC No.216-133-4 / 244-240-6, INCI: Acetyl Hexamethyl Tetralin) is an ingredient listed in the Cosing, with the function: Fragrance.
The substance is included in Annex III/182 of the European Cosmetics Regulation 1223/2009, which limits its use to 0.1% in leave-on products (except in hydroalcoholic products: 1%, fine fragrance: 2.5%, fragrance cream: 0.5%) and ti 0.2% in rinse-off products.
It is not currently listed in Annex VI of European CLP Regulation 1272/2008.
Germany proposes to classify the substance as follows.
Identification
Index number
• TBD
Chemical name
• 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one
EC numbers
• 216-133-4 / 244-240-6
CAS numbers
• 1506-02-1 / 21145-77-7
Classification
Hazard class and Category code(s)
• Repr.1B
• STOT RE 2
• Aquatic Acute 1
• Aquatic Chronic 1
Hazard statement code(s)
• H360Df - May damage the unborn child. Suspected of damaging fertility.
• H373 (liver, thyroid) - May cause damage to organs through prolonged or repeated exposure.
• H400 - Very toxic to aquatic life.
• H410 - Very toxic to aquatic life with long lasting effects.
Labelling
Pictogram, Signal word code(s)

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