On 17 June 2026, ECHA (the European Chemicals Agency) forwarded Belgium’s proposal for the harmonised classification and labelling (CLH) of n-Phenyl-p-Phenylenediamine, a hair dyeing ingredient.
N-(4-aminophenyl)aniline (CAS No.101-54-2, EC No.202-951-9, INCI: n-Phenyl-p-Phenylenediamine) is an ingredient listed in Cosing, with the function: Hair dyeing.
The substance is regulated by Annex III/8 of the European Cosmetics Regulation 1223/2009, which stipulates that “after mixing under oxidising conditions, the maximum concentration applied to the hair must not exceed 3 per cent, calculated as the free base”, and requires the labelling to include precautions for use and other warnings.
It is not currently listed in Annex VI of the European CLP Regulation 1272/2008.
Belgium proposes to classify the substance as follows
• Acute Tox. 4, H302 - Harmful if swallowed.
• Eye Irrit. 2, H319 - Causes serious eye irritation.
• Skin Sens. 1A, H317 - May cause an allergic skin reaction.
• Aquatic Acute 1, H400 - Very toxic to aquatic life (M-Factor = 1).
• Aquatic Chronic 1, H410 - Very toxic to aquatic life with long lasting effects (M-Factor = 1).
With the following specific concentration limit
• Oral: ATE = 300 mg/kg bw.
