The ICCS Good Practice Guide (BPG) provides a concrete methodological framework for assessing the risks of serious eye damage and eye irritation using new assessment methodologies (NAMs). Its purpose is to support safety assessors in the transition from traditional methods based on animal testing to alternative approaches. It therefore advocates the use of scientifically robust, transparent, and harmonized methods for identifying hazards and assessing the safety of substances used in cosmetic products.

This guide is based on a six-step structured approach designed to guide evaluators throughout the evaluation process:
• defining the problem,
• characterizing the substance,
• considering exposure,
• reviewing available data,
• conducting targeted tests,
• analyzing the results.
Particular attention is given to the characterization of uncertainties, the traceability of decisions, and the integration of all relevant data to ensure scientifically sound conclusions. The document also addresses OECD-recognized evaluation methods (NAMs), integrated testing and evaluation approaches (IATAs), defined approaches (DAs), and the use of complementary methods as part of an evidence-convergence-based approach.

Intended for safety evaluators seeking to expand the use of alternative methods, this guide serves as a practical tool for implementing the principles of next-generation risk assessment (NGRA) in the field of …