This call for data applies to Phytonadione Epoxide (CAS No.25486-55-9, EC No.247-022-9).
The substance, listed in the CosIng as an astringent and skin protecting agent, is not currently regulated by European Cosmetics Regulation 1223/2009.

The context

In cosmetics, Vitamin K1 was used for moisturizing, skin lightening, and treating bruising and hyperpigmentation. However, multiple cases of allergic contact dermatitis (ACD) linked to topical vitamin K1 use were reported, leading to its ban in cosmetic products in 2009.
To replace it, the cosmetic industry introduced Phytonadione Epoxide (Vitamin K oxide), a synthetic or naturally occurring oxidized form of Vitamin K1 (phytonadione).

Phytonadione Epoxide is primarily used as a skin conditioning agent with possible effects in reducing the appearance of dark under-eye circles, redness and improving skin tone uniformity. It is often marketed in eye creams, anti-aging serums, or redness-correcting formulations, sometimes combined with other vitamins to enhance its function.

But the use of Phytonadione Epoxide too has caused ACD, including severe skin reactions and photoinduced responses. Recent years have seen a rise in reported ACD cases to phytonadione epoxide in Spain, particularly from eye contour products.

Diagnosing ACD to phytonadione epoxide has proven challenging, as standard patch …